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As mentioned earlier, sperm membranes are rich in PUFAs, which are particularly prone to oxidation by ROS

Adult female mice exposed to the early-life HFHS diet displayed alterations in circulating metabolites belonging to different metabolite classes, including the microbiota-derived metabolites kynurenine, indole-3-carboxaldehyde, hippuric acid, or pantothenic acid, and the host-derived metabolites creatinine, creatine, tryptophan, 15(S)-HETE, lactic acid or the L-amino acids alanine and arginine (Fig

5g, middle panels, lanes 2 and 3)

acknowledges support from the Deutsche Forschungsgemeinschaft (FerrOs- FOR5146

It's biochemically inactive, converting an expensive research compound into sterile water