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Alpha-lipoic acid (ALA) mitigates ferroptosis by activating the PPAR/NRF2/GPX4 pathway, enhancing antioxidant defenses, and improving pregnancy outcomes in unexplained RM

However, unlike glucose and part of amino acids, excessive cholesterol uptake by CD8 + T and CD4 + T cells inhibits their function

Discussion In this study, we demonstrate that replication fork reversal and chromosome mis-segregation induced by HRASV12 or cyclin E1 overexpression are mainly caused by R-loops that appear to form specifically in S-phase, possibly during transcription-replication encounters