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Other pharmaceutical agents, including the immunosuppressive drugs azathioprine (Imuran) and 6-mercaptopurine, the anti-cancer drug 5-fluorouracil (5-FU, Adrucil), and levodopa/carbidopa (Sinemet

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54 Proximal tubular hypertrophy, a compensatory response to chronic hyperglycemia, triggers metabolic reprogramming, hypoxia, adenosine triphosphate (ATP) depletion, immune cell recruitment, and cytokine release

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Studies have demonstrated that methylation of histone H3 at lysine 4, lysine 9, and lysine 27 is a critical and dynamic epigenetic modification occurring during HSC activation