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8G and S7C)

[109] Melatonin is also known to modify many cytokines, including TNF, IL1, IL-2, IL-6, and gamma-interferon, in ways consistent with increased host defense against cancers

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Rarely, if the nodule is very large, the patient may also develop symptoms due to the enlarged thyroid gland such as difficulty with breathing or swallowing (as the enlarged gland may press on the food or wind pipes, which are located nearby)