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The safety profile of topical GHK-Cu is well-established across decades of use and multiple clinical trials

activation remains weeks 14

Malabsorption from coeliac disease, Crohns, gastric surgery or long-term metformin and proton-pump inhibitors accounts for much of the rest

Additionally, through the activation of the SIRT1 gene known for its role in longevityit contributes to anti-aging by promoting healthy, resilient cells

While preclinical findings are encouraging, human clinical evidence remains limited , and the compound should be viewed as a research-stage metabolic therapy rather than an established treatment for obesity or weight management