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In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

Nanoscale 9 , 1601216023 (2017)

This leads to the accumulation of oxidative stress products (e.g., 8-isoprostane), which exacerbates inflammation, damages airway epithelial cells and pulmonary macrophages, and impairs mucociliary clearance function ( Oxidative stress further suppresses the antioxidant system

utilized chitosan in complex with sodium triphosphate to coat liposomes, and conducted a comprehensive characterization of the systems effectiveness and feasibility

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