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The global prevalence of DE is estimated to range from 5% to 50%, positioning it as a significant public health issue worldwide [3]

L 0 is the concentration of ligand (usually 10 -4 - 10 -2 M) K D is the equilibrium dissociation constant K D can be changed by pH, ionic strength, temperature and other parameters

This inhibitory action on 3CLpro is dependent on the hydroxyl group of quercetin which, as shown through molecular modeling and Q189A mutation, recognizes Gln189 as a crucial site on 3CLpro responsible for the binding of quercetin (102)

doi: 10.1111/jgh.15631 135 HanJLeeCJeongHJeonSLeeMLeeHet al

Trkb Penk-KO , n = 4