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Again, theyre not competitors

Studies have found that berberine attenuates ischemia-reperfusion injury through NF-B nuclear translocation in mice with transient cerebral artery occlusion, however, this neuroprotective effect was more pronounced at the high dose (50 mg/kg) than the low dose (25 mg/kg) (Zhu et al., 2018)

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

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BDNF is expressed at high levels in the VMN, where its expression is modulated by MC4R signaling