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Other potential benefits: Research is ongoing to investigate the potential benefits of vitamin D3 for various conditions, including: Heart disease Diabetes Certain cancers Autoimmune diseases Depression

While some ROS generation, produced via NADPH-dependent NOX and iNOS, is advantageous and necessary for pathogen clearance, it must be carefully titrated by antioxidant GSH which is itself regulated by NADPH-dependent glutathione reductase

Pharmacogenomics, the study of the role of genetics in drug response, was introduced to optimize the treatment while minimizing drug-related toxicity using SNPs as molecular markers, forming the basis for precision medicine ( 2 Method This manuscript is a narrative review article

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