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A notable clinical trial involving oral semaglutide ( Rybelsus ) showed substantial weight loss in participants over 68 weeks

Nine, seven, and three DEGs involved in the top 3 terms in biological process under glutathione metabolic process, toxin catabolic process, and cellular response to oxidative stress

Beyond direct regulation of neuronal excitability via synaptic plasticity, PICs can also enhance neuronal excitability by activating glial cells and promoting A1 (astrocytic) or M1 (microglial) polarization, leading to further release of pro-inflammatory cytokines

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