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The FDA has consistently made the widest use of the FRPs compared with other regulators and has achieved the shortest time to approval amongst leading NRAs

Castillo-Prez, E

(2020) 36:e3213

doi: 10.1016/j.taap.2021.115853 92

In summary, the crosstalk between autophagy and ferroptosis is governed by a complex, context-dependent network encompassing three core modes: i) Negative regulation, primarily through mTOR signaling and mitophagy, to inhibit ferroptosis