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NICE NG28 similarly recommends considering periodic monitoring of B12 in people at risk on long-term metformin this is not a blanket recommendation for all metformin users, but is targeted at those with relevant risk factors or symptoms

As with any emerging pharmacological agent, the establishment of a safe and effective dosage for clinical use necessitates thorough and rigorous clinical trials

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It's easy to get excited about the potential benefits, but it's just as important to be realistic about the risks

35839643) Renal failure, including dialysis : Generally, no dose adjustment is required