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NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1 pathway

doi:10.3389/fimmu.2018.02069 19

Adesanya AW, Lavine MD, Moural TW, Lavine LC, Zhu F, Walsh DB

The transport of molecules across the epithelial layer occurs through three major pathways: the trans-cellular pathway (passive diffusion across the cell membranes), the carrier-mediated pathway (carrier/receptor-mediated trans-cellular pathway), and the paracellular pathway (passive diffusion between the spaces through adjacent cells)