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(4) Inhibition of the electron transport chain: -syn aggregation impedes ATP production and increases the generation of ROS by diminishing the activity of mitochondrial complex I (Indrieri et al., 2020

Harb Z, Deckert V, Bressenot AM, Christov C, Gueant-Rodriguez RM, Raso J, Alberto JM, de Barros JPP, Umoret R, Peyrin-Biroulet L

PG Polygold

This biochemical profile correlates strongly with worse clinical progression, higher inflammatory markers, and the onset of severe neurological sequelae