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Copper depot formation and penetration was studied using: Isolated stratum corneum (Experiment A) Entire epidermis, including stratum corneum (experiment B) Split thickness skin comprising stratum corneum, epidermis and underlying dermis tissue (experiment C) Tissue preparation Human cadaver skin was obtained from the Northern California Transplant Bank (San Rafael, CA) and stored in a freezer (20C) until use

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One can experience some discomfort, bruising, itching, inflammation, or redness at or around the site of injection of the catheter which could last from a few minutes to several days

The starting conformations were obtained by manually binding GS(H) to a snapshot of the MD simulation of TRaQ-G and the crystal structure of MeTRaQ-G, respectively