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Deepening our understanding at the molecular level will not only optimize therapeutic efficacy but also inspire the development of innovative delivery systems and next-generation peptide drugs

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552 M1-mAChR positive allosteric modulators (M1-PAMs), such as BQCA ( 53 ) and PF06764427 ( 54 ), achieve subtype selectivity through allosteric effects but have significant agonistic activity that may lead to side effects like diarrhea