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In brief, the numbers of MDSCs significantly increase with aging both in the circulation of humans and mice [127, 128]

Fatty liver, in which fat is deposited in the liver tissue, is thought to progress to non-alcoholic steatohepatitis and liver cirrhosis (NASH) when the tissue is exposed to certain stimuli such as oxidative stress and inflammatory cytokines

60 The rise in the serum levels of pro-inflammatory cytokines are also observed in SARS-CoV and MERS-CoV infection, suggesting a potentially similar cytokine storm-mediated disease severity