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This represents a so far unexplored mechanism of how pathogens are able to reprogram their virulence and to precisely adjust their infectivity to the environment, i.e., the metabolic state, and to their own fitness and/or the fitness of the infected host cells

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It must be assessed and closely monitored on an individual basis

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The diagnosis of PFPT had been made based on clinical findings of circumscribed pigmentation localized on fungiform papillae of the tongue and also in association with dermoscopic findings