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The role of mitochondrial dehydrogenases in the generation of oxidative stress

Introduction You have likely heard glutathione described as the "master antioxidant" of the human body

and PPM1A/PP2C, which directly dephosphorylates YAP and promotes the nuclear distribution of YAP

This may be useful as a model for increasing resilience to stressors in at-risk populations. The above study shows that LAC enhances resilience to stress

In the canonical TCA cycle, in addition to pyruvate-derived acetyl-CoA, oxidation of fatty acids or glutamine can be used to produce ATP and intermediates