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The integration of multimodal omics datasets with advanced computational methods provided important information for biomarker discovery, for the development of predictive algorithms for clinical application

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These studies indicated that in response to oxidative stress, there is not only an increase in expression of both PA28 and PA28 over the subsequent 24 h, but also enhanced capacity of the 20S proteasome to selectively remove oxidative damaged proteins (Pickering and Davies, 2012b)