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When levels drop, due to age, stress, poor sleep, or environmental exposure people often notice symptoms like fatigue, dull skin, inflammation, brain fog, and frequent illness

Generally GM breaks down hosts food to fulfill its nutritional requirements, along with they generate metabolites like neurotransmitters or their precursors, which impact existed neurotransmitters level in brain

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Supporting this, studies indicate that treatment with insulin or insulin-sensitizing drugs effectively reduced tau hyperphosphorylation in neurons [132, 133]

Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, and surgical methods