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In order to provide further evidence that the oxidized species of strep-MBP-ROXY9 indeed contains the expected disulfide between Cys21 and Cys24, strep-MBP-ROXY9 variants with either SCLC or CCLS sequences in the active site were analysed (Supplementary Fig

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The majority of renoprotective claims derive from rodent models (primarily db/db mice, streptozotocin-induced diabetes, or high-fat diet models), which exhibit fundamental differences from human DKD in gut microbiota composition, metabolic kinetics, and disease progression timelines

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