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highlighted that the rapid turnover of synovial fluid poses a challenge to sustained expression, underscoring the importance of incorporating physical carriers to protect and localize gene payloads (180)

A landmark intervention trial in diabetic patients found that a high mixed-fiber diet selectively promoted the proliferation of SCFA-producing bacterial strains, particularly enriching bacteria carrying carbohydrate-active enzyme-encoding genes, thereby significantly improving glycated hemoglobin levels and postprandial glucose responses (33)

10.5114/fn.2022.122800 Folia