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Lin Xin et al., using methionine-deficient culture in nude mouse gastric cancer models and human gastric cancer xenografts, found that long non-coding RNA PVT1 levels were downregulated, subsequently affecting BCL2/Adenovirus E1B 19 kDa Interacting Protein 3 (BNIP3) expression (41)

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Evidence suggests that the bone microenvironment significantly contributes to the development of secondary metastases in other organs [45,46,47]

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