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Peptide-modified mesoporous silica nanoparticles for the coordinated regulation of macrophage polarization and pyroptosis in the treatment of implant-related infections

Specific elimination of senescent chondrocytes by NPs To study the specific elimination of senescent chondrocytes by the NPs, DOX-induced senescent ATDC5 cells were seeded on a 48-well cell culture plate (5 10 4 cells per well)

J Pharmacol Exp Ther 2004

and v) in the rats, which underwent delayed therapy, at 48 h postL-NAME administration: immediately before medication ( A ) and after application ( B , C , D , E , F , and G ), immediately after ( B ), and after 1 and 2 days, corresponding to day 3 (C) and day 4 ( D ) L-NAME time, and at the days 7 ( E ), 14 ( F ), and 28 ( G ) L-NAME time