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SSR504734 in another study also showed anticonvulsive effects in the PTZ model in a single-dose regimen, although the effects were not consistent across all models tested (Gapiska et al

The equilibrium between mitochondrial dynamics and mitophagy is essential for the continuous renewal of mitochondria and the generation of new mitochondria (Palikaras and Tavernarakis, 2014)

Research found that a decreased network response to stimulation in both excitatory and inhibitory circuits of the sensory cortex of Nlgn4 knock-out animals as compared to wild-type controls, and a decreased excitation-inhibition ratio, suggesting that Nlgn4 is involved in the regulation of excitatory and inhibitory circuits and contributes to a balanced circuit response to stimulation (88).Another study reports, Nlgn4 knockout disrupts GABAergic synaptic transmission and oscillatory activity in the hippocampus and causes deficits in social interaction