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Oliai Araghi S, Kiefte-de Jong JC, van Dijk SC, Swart KMA, van Laarhoven HW, van Schoor NM, de Groot LCPGM, Lemmens V, Stricker BH, Uitterlinden AG, van der Velde N

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As previously mentioned for NRF2 regulation, a predominant reliance on glycolysis over mitochondrial OXPHOS for energy demands supports NSCs stemness by relatively lower mitochondrial ATP production, reduced ROS production, and enhanced antioxidant capacity, which are critical for protecting stem cell genomic integrity and preventing premature differentiation (Zoccarato et al., 2022)

Moreover, they influence enzymes such as PTK, PKC, XO, iNOS, and COX-2 to impede tumor cell proliferation and regulate the cell cycle across different phases (S/G2, G1, S, and G2) (Hazafa et al., 2020)