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Regarding neurodevelopment, Zn supplementation was found to improve minimally the executive function and motor development (326) or have no global effect (327), while supplementing mothers during pregnancy was not found to improve long term developmental outcomes (324, 325)

253,254 Therefore, chemical modification at this specific position could improve siRNA binding affinity

Similarly, impaired GH release after exposure to dexamethasone was also found in patients exposed to organophosphates (153)

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