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Mechanistically, these mediators suppress proinflammatory cytokine production, reduce the recruitment and infiltration of Th1 and Th17 cells, and increase the proportion of Tregs [288]

Notably, mitochondrial transplantation into the medial forebrain bundle has been shown to ameliorate motor deficits in 6-hydroxydopamine-induced PD rats, enhancing mitochondrial functionality (184)