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Handling and Storage Recommendations Store unopened vials at 28 C , with 20 C recommended for long-term storage Protect from light and moisture After reconstitution, store solutions at 28 C and use within laboratory-defined timeframes Avoid repeated freeze-thaw cycles Follow standard laboratory safety, labeling, and handling procedures All handling is performed within laboratory research environments

once reconstituted, refrigerate at 28 C and do not freeze

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The patients in whom we have observed less meaningful response tend to be those who have not addressed the foundation, who have unrealistic expectations, or who have other factors (significant sleep restriction, untreated metabolic comorbidities, chaotic eating patterns) that any pharmacological adjunct would struggle against