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Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)

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Dermatomyositis is one of the five main clinicopathologically distinct inflammatory myopathies, the other four being (1) polymyositis, (based on the historical classification, even if now seemingly extinct), (2) necrotizing autoimmune myositis, (3) overlap myositis and the anti-synthetase syndromes, and (4) inclusion-body myositis (24)

doi: 10.1002/jnr.21483 135 LiuWLiYJalewaJSaunders-WoodTLiLHlscherC

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