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High-dose vitamin B12 therapy has been shown to be effective in reducing neuropathic pain in patients with diabetic neuropathy, highlighting its potential as a valuable treatment option . More research has looked at how different ways of taking B12 work

It is, therefore, contraindicated in patients with a history of or active peptic ulcer disease, GI bleeding, or GI perforation

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A preliminary study of eleven consecutive patients evaluated individuals suffering from diabetic peripheral neuropathy who were treated with a combination of L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate (active Vitamin B6)