genital melanotic macules pictures macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Dermatoscopic image of genital melanotic

McQueen T, Konopleva M, Andreeff M

Treatment with MAO inhibitors and HT could mitigate the elevation in cerebrospinal fluid Cys-DA thus slowing the neural degeneration

It is characterised not just by lysosomal enzyme deficiencies but also by the impact this has on inflammatory pathways

The combination is appealing because using a GHRH analogue such as CJC-1295 with a secretagogue like Ipamorelin potentially allows lower frequency dosing, better control over GH peaks/troughs, and possibly fewer side effects from GH overshoot or non-GH hormone activation

Patients with recurrent drug-induced priapism who require long-term antipsychotic therapy necessitate psychiatry and urology comanagement, with likely use of adjunctive medications (eg, gabapentin, baclofen, or pseudoephedrine)