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To compare the model with other reported CRBN structures, every reported closed conformation CRBN structure in complex with a molecular glue degrader or a PROTAC was superimposed (PDB ID 4TZ4, 5FQD, 5HXB, 5V3O, 6BN7, 6BN8, 6BN9, 6BOY, 6H0G, 6UML, 6XK9, 7LPS, 8D7U, 8D7V, 8D7W, 8D7Z, 8D80, 8D81, 8DEY, 8G66, 8OIZ, 8OJH, 8TNP, 8TNQ, 8TNR, 8TZX, 8U15, 8U16, 8U17) to the C terminus domain (aa 318-442) of the CRBN in the model 1517,19,57,77,82,145151

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