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Similar content being viewed by others Introduction Post-translational modifications (PTMs) increase the protein structure and function diversity by adding covalent chemical adducts to proteins, thereby regulating various biological processes and influencing the pathophysiologic progression of diseases, including cancer 1,2,3

The six-transmembrane epithelial antigen of prostate family member 3 (STEAP3), a metal reductase, reduces Fe 3+ to Fe 2+ in the endosome, ultimately releasing free iron into the cytosol

Important Safety Information: The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects

Netto MV, Mohan RR, Sinha S, Sharma A, Dupps W, Wilson SE

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