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Several molecules involved in the signal transduction processes, including small GTP-binding proteins and tyrosine kinases, such as c-Src, c-Yes, and protein kinase C (PKC), have been found to be localized at these tight junctions, presumably indicating their pivotal role in the maintenance of tight junction integrity 54,55

Notably, the pK of the resulting metal-NA complexes as well as the pH of the solution (with most metals being chelated at neutral or basic pH values) were considered to significantly control the ability of NA to chelate metals (Relln-lvarez et al., 2008)

September 2010