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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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This accuracy prevents misdosing, which is a significant, sometimes dramatic shift, in your experimental variables

We recommend keeping it in the original sealed vial until you are ready to use it

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