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We then evaluated whether LCN2 ablation affects antioxidant defenses that counteract ferroptosis, focusing on the cystine/glutamate antiporter System Xc (encoded by Slc7a11/SLC7A11/xCT) and glutathione peroxidase (GPX4), which together mitigates oxidative stress by promoting cystine import and glutathione synthesis [11, 30]

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