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The combined effect supports better blood sugar control and may reduce appetite

To understand this increased susceptibility in some people, it is useful to know how acetaminophen is processed (metabolized) in the liver and how the drug causes liver injury

Feldman, Nave, Jensen, & Bennett, 2017)

When combined, these overlapping side effect profiles may worsen GI tolerability, particularly during the dose escalation phase when tirzepatide GI effects are already at their peak