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As is shown by our previous work 27 , CcSOD1 could retain stable activity within a wide range of temperatures (1070 C), and was also highly stable at a wide pH range (pH 49), exhibiting a higher stability than some reported SODs from other organisms

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Low-affinity insulin-like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival

However, despite this contributory role, it is not reasonable to propose direct therapeutic targeting of vascular dysfunction or BBB endothelial cells as a primary strategy for treating neurodegenerative disorders

The SOX4/EZH2 axis-mediated H3K27me3 epigenetic silencing plays a crucial role in its regulatory effects [51]