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Among the specific anticoagulants discovered are the kininogen cleaving serine protease Sk1, the - and -thrombin binding/inhibiting membrane bound antigen Sm 22.6, the ATP-diphosphohydrolase enzyme Sm ATPDase1 that cleaves the platelet activator ADP, the more recently characterized tegumental calpains S, Calp1 and Sm Calp2 that cleave host fibrinogen, and finally, the secreted serine protease Sm SP2 that activates parts of the fibrinolytic system and promotes vasodilation (162165)

doi: 10.1016/j.alcohol.2012.03.004 94 KumarS.PorcuP.WernerD

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There is compelling evidence that the RhopH proteins participate in NPP formation, but there are still fundamental questions concerning the makeup of NPP that need to be determined, particularly the component(s) that form the actual channel through the erythrocyte membrane

This effect was alleviated with both genetic and pharmacological inhibition of adipocyte lipolysis, which decreased hepatic acetyl-CoA levels and gluconeogenesis, thereby normalizing plasma glucose in mice fed with high fat diet (HFD) (183)