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In tissues, the ketosteroid isomerase reactions catalyzed by GSTs are strictly dependent on dehydrogenases such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase for production of the 3-keto substrates from the corresponding 3-hydroxysteroid precursors, since the GSTs are lacking dehydrogenase activity

In addition, DLPFC is also rich in mGluR2 [94, 95], and several pieces of evidence have shown that it is the most damaged by COVID-19, which can explain the cognitive dysfunction also observed in long COVID [28, 86]