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doi: 10.1038/s41467-018-07598-9 [DOI] [PMC free article] [PubMed] [Google Scholar] 513

Other conditions associated with elevated B12 include: Chronic inflammatory states and autoimmune conditions Macro-B12 (B12 bound to immunoglobulins) causing laboratory assay interference without clinical significance Acute inflammatory responses Supplementation and medication should always be considered

A healthy cortisol rhythm involves a morning spike (the Cortisol Awakening Response) to wake us up, followed by a gradual decline throughout the day, reaching its lowest point at night to facilitate sleep