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Researchers have commented that the peptide appears to cause increases in mean plasma GH concentrations by 2- to 10-fold [...] and in mean plasma IGF-I concentrations by 1.5- to 3-fold... [2] CJC-1295 has been primarily researched for its potential in mitigating actions frequently associated with cell aging

This has prompted WADA to evaluate possible misuses of gene editing for doping and as a consequence, has included these technologies in the definition of Gene Doping since the 2018 Prohibited List

These reactions are usually minor and resolve within hours to days

downstream IGF-1 axis effects under varying protocol frequencies