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An increased risk of lung cancer has been reported in survivors of hereditary retinoblastoma with germline RB1 mutations, with lung cancer diagnosis tending to occur before 40 years of age 223 , and there are case reports of lung cancers associated with Bloom 224 , Werner 225 and BirtHoggDube syndromes 217

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These include: Numbness or tingling in the hands and feet Difficulty walking Balance problems Mood changes, such as depression These symptoms affect the nervous system

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