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This strategy, known as head-to-tail cyclization, can enhance the peptides structural integrity and biological activity

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In addition to MYC, mutations in the key gene KRAS, which are associated with c-MYC protein stability and activity, similarly result in dependence on exogenous glutamine for cell growth and proliferation

Future research should aim to standardize diagnostic frameworks and stratify patients based on molecular or clinical subtypes to improve study reproducibility and relevance

These are implicated in the pathogenesis of AD and used as an indicator of disease severity