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Mendias, C

doi:10.2147/CIA.S143508

Many providers use Tesofensine as an add-on rather than a replacement because it helps increase energy expenditure while the GLP-1 continues appetite regulation

Pharmacokinetic studies using radiolabeled versions of the peptide reveal rapid absorption after injection, with peak concentrations achieved within 3 to 6 minutes following intramuscular administration

The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]