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Studies reported that AFs could dysregulate the cellular levels of PKC, PKA, p53, CDK, NF- B, Bcl2, CKI , and cyclins (276)

Under physiological conditions, extracellular Cu 2+ is reduced to Cu + by reductases such as STEAP, imported by copper transporter 1 (CTR1, also termed SLC31A1), and then escorted to specific sub-cellular destinations by dedicated chaperones

Par consquent, le fait de voir un VGM dans la norme et un compte correct drythrocytes dans une analyse ne signifie pas quil ny a pas de risque de dvelopper une symptomatologie non hmatologique propre la carence en B12, mme si lanmie mgaloblastique ne se manifeste pas (ou peut se manifester de manire lgre ou trs lgre)