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In the KO mice, elevated levels of triglycerides and VLDLs were identified

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Pritchard, M

Phase 2 clinical trials showed some positive outcomes, but these were not sufficiently significant over a treatment period of 7-10 days, leading to the halt of development [11, 12]

Drug screen in SK-MEL-103 with selected electrophilic compounds in combination with cell death inhibitors Selected electrophilic compounds were tested in SK-MEL-103 cells in the presence of apoptosis or ferroptosis inhibitors (emricasan and liproxstatin 1, respectively)