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Whether the mitochondrial dysfunction in RA can be associated with ferroptosis and what kind of ferroptotic cells should be linked to the mitochondrial dysfunction in RA still need further research and exploration

Molecular chaperone peptides B-crystallin (HSPB5) and its peptide derivatives, studied to protect dermal proteins against aggregation and oxidative damage in photoageing

Such damage can further lead to mitochondrial dysfunction, triggering apoptosis or necroptosis, which represents a key pathological process in oxidative stress [61]

doi: 10.1111/ctr.13289 22 LeitheiserSHarnerAWallerJLTurrentineJBaerSKhedaMet al

Ramadan et al., 2022